What we do
About our project
What is the motivation for this research?
Keloids and hypertrophic scars are dysregulated immune responses to cutaneous wound healing and can be associated with substantial physical and psychological distress. Current first-line therapy is triamcinolone administered via conventional needle injections, however, this is associated with (severe) pain and frequent recurrences. Research suggests that bleomycin, an antineoplastic antibiotic, is a promising treatment option and reduces the number of recurrences in keloids and hypertrophic scars. Dermal bleomycin administration using energy-based drug delivery techniques, such as electronic pneumatic injection or ablative fractional laser, could be more effective, faster and less painful treatment options for keloids and hypertrophic scars.
What is the aim?
We aim to investigate the working mechanism, efficacy, and tolerability of energy-based drug delivery of bleomycin in keloids and hypertrophic scars.
How will you perform this study?
By systematic literature searches, translational research and clinical research with healthy volunteers and patients, in collaboration with national and international experts in the field of energy-based drug delivery in dermatology.
What do you hope to achieve?
To achieve a better understanding of energy-based drug delivery of bleomycin in an ex vivo and in vivo research setting. Additionally, to reduce the number of treatments and recurrences in keloids and hypertrophic scars, while improving patient satisfaction.
Department of Pathology, Erasmus MC
Dr. Albert Wolkerstorfer, MD, PhD, Department of Dermatology, Amsterdam UMC, Amsterdam, The Netherlands (www.amsterdamumc.nl/)
Prof. Dr. Merete Haedersdal, MD, PhD, DMSc, Department of Dermatology, Bispebjerg hospital, Copenhagen, Denmark (www.bispebjerghospital.dk/english)
Dr. Robert Rissmann, PharmD, PhD, Center for Human Drug Research, Leiden, The Netherlands. (www.chdr.nl)
Martijn van Doorn, MD, PhD, dermatologist – clinical pharmacologist
Prof. Errol Prens, MD, PhD, dermatologist - immunologist
Jeffrey Damman, MD, PhD, pathologist