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Research project

Neonatal erythroderma & collodion

Status: Ongoing

We investigate the characteristics and causes of neonatal erythroderma and collodion babies using a multidisciplinary national protocol with Next Generation Sequencing.

What we do

About our project

Background information 

The management of neonatal erythroderma is difficult group because this condition has many possible underlying causes. Many of the affected children experience a chronic benign course, but immunodeficiencies can lead to complications and death if not treated on time.

Overall aim 

The main objective of the study is to find a definite diagnosis in a short time before complications occur. The best treatment can then start.

Research method 

A multidisciplinary protocol is used nationwide in the Netherlands. For genetic analysis, the Wilhelmina’s Children Hospital (WKZ) in Utrecht actively participates using Next Generation Sequencing on the basis of a dedicated gene panel.

Desirable outcome

Through this study we hope to obtain more detailed information about patients with neonatal erythroderma and collodion babies that can help us finding a diagnosis fast, preferably within two weeks.

Neonatal Erythroderma


Congenital erythroderma should be considered as an urgent warning sign of immunodeficiency: a case of Omenn syndrome.Cuperus E, Montfrans JMV, Gijn MEV, Bastiaens MT, Willigen MM, Leguit RJ6, Brijnzeel-Koomen CA, RusseL IM, Pasmans SG. (2017). Eur J Dermatol. 2017 Jun 1;27(3):313-314.