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Petri dish
Research project

Sonobactericide to treat bacterial infective endocarditis

Status: Ongoing

This project is using ultrasound and microbubbles for sonobactericde (Erasmus MC fellowship Kooiman)

What we do

About our project

What is the motivation for this research?

Infective endocarditis is a life-threatening bacterial infection of the heart. Currently, treating infective endocarditis is costly, lengthy, and difficult because the biofilm of bacteria are encapsulated within a vegetation (thrombus-like mesh). Moreover, the morbidity and mortality rate of infective endocarditis is high.

What is the aim?

The main objective is to use ultrasound-activated microbubbles (1-10 μm in diameter) for local antibiotic delivery.

How will you perform this research?

We will develop enhancement of bactericidal action aided by ultrasound and the presence of microbubbles, i.e. sonobactericide. The research focuses on preclinical research and tissue obtained from infective endocarditis patients who are operated to replace the infected valve.

What is the desirable outcome?

Sonobactericide could potentially be used to overcome infective endocarditis by directly inducing bacterial death.

Funds & Grants

Erasmus MC Fellowship


Collaborations within Erasmus MC

Cardiothoracic Surgery
Medical Microbiology & Infectious Diseases (MMID)

Collaborations outside Erasmus MC

Image-guided Ultrasound Therapeutics Laboratories, University of Cincinnati, Holland lab  
Laboratory of Acoustical Wavefield Imaging, Delft University of Technology


Our team

Any questions or comments?

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Contact form