Jump to top menu Jump to main menu Jump to content
Atherosclerosos Biomechanics
Research project

Biomechanics and Atherosclerosis

Status: Ongoing

This research project studies the influence of biomechanical stress on the development, progression and rupture of atherosclerotic plaques.

What we do

About our project

Atherosclerosis is the leading cause of death world-wide and atherosclerotic plaque rupture is the underlying pathology related to the majority of cardiovascular events. Biomechanical forces are known to be involved in the initiation, progression, destabilization and rupture of atherosclerotic plaques. Therefore, we envision a role for biomechanical stress to identify plaques at risk to be used during clinical decision making.

 

Atherosclerosos Biomechanics

Our research focus

In our studies we make use of in vitro studies, (pre)-clinical models of atherosclerosis and patients. During the different phases of the disease, atherosclerotic plaque progression is monitored using (non)-invasive imaging and plaque tissue is collected. Acquired images are used to 3D reconstruct the lumen and vessel wall of the artery under study. Using image based modeling the local stress in and at the vessel wall are computed using finite element modeling (see figure) and finally linked to local changes in the vessel wall, including the vessel wall composition. This methodology allows for a very detailed analysis of the influence of local stress on the pathophysiology of plaque changes.

Funds & Grants

  • ERC
  • VENI
  • TTW
  • INSILC

Collaborations

Internal collaborations

External collaborations

Publications

Our team

Any questions or comments?

Please contact our office.

Contact form