What we do
About our project
Atherosclerosis is the leading cause of death world-wide and atherosclerotic plaque rupture is the underlying pathology related to the majority of cardiovascular events. Biomechanical forces are known to be involved in the initiation, progression, destabilization and rupture of atherosclerotic plaques. Therefore, we envision a role for biomechanical stress to identify plaques at risk to be used during clinical decision making.
Our research focus
Funds & Grants
- Department of Biomechanical Engineering, 3ME, TU Delft, the Netherlands
- Prof. Umberto Morbiducci, Politecnico di Torino, Torino, Italy
- Prof. Peter Stone, Bigham and Women’s Hospital, Harvard Medical Center, Boston, USA
- Prof Alfons Hoekstra, UVA, Amsterdam, NL
- Prof. C Bouten, Eindhoven University of Technology
- Hoogendoorn et al. Multidirectional wall shear stress promotes advanced coronary plaque development - comparing five shear stress metrics. Cardiovasc Res. 2019 Aug 22. pii: cvz212. doi: 10.1093/cvr/cvz212.
- Gijsen et al . Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. Eur Heart J. 2019 Nov 1;40(41):3421-3433. doi: 10.1093/eurheartj/ehz551
- Moerman et al. An MRI-based method to register patient-specific wall shear stress data to histology. PLoS One. 2019 Jun 6;14(6):e0217271.
- Kok et al. The influence of multidirectional shear stress on plaque progression and composition changes in human coronary arteries. EuroIntervention. 2019 Oct 20;15(8):692-699.
- Barrett et al., Calcifications in atherosclerotic plaques and impact on plaque biomechanics. J Biomech. 2019 Apr 18;87:1-12,
- Meester et al., Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with 111In-DANBIRT. J Nucl Cardiol. 2019 Oct;26(5):1697-1704.