I was trained as a mechanical engineer, and did my PhD on experimental and numerical analyses of blood flow in large arteries. My current research topics are in the domain of image-based biomechanics of the cardiovascular system. My main interests include the influence of blood flow induced wall shear stress on atherosclerotic plaque progression, composition and rupture. Furthermore, I focus on plaque biomechanics in order to assess the mechanical stability of coronary and carotid plaques. For both research topics, I combine state of the art finite element analysis of both the blood flow and plaque mechanics with the latest imaging modalities.
- Plaque rupture experiments through uni-axial tension tests and inflation experiments
- Inverse finite element methods for determination of plaque properties
- Blood flow and stents: can we predict in stent restenosis?
- Multiscale modeling of in stent restenosis
- Plaque mechanics: what is the role of calcifications on stress distribution?
- Tissue Engineering a human disease model for atherosclerosis
- Determining the lipid profile of human atherosclerotic plaques
- Linking MRI-based shear stress calculations to human carotid plaque composition
- Experimental characterization of human thrombi
Field(s) of expertise
- Cardiovascular Biomechanics
- Atherosclerotic Plaque Imaging
- Rupture Mechanics
- Computational Fluid Dynamics
Education and career
- Supervised 7 PhD theses to date
- Supervised numerous MSc and BSc theses and internships.
- Participated in various educational programs on a national and international level.
- Associate Editor Journal of Biomechanics, 2017 – present
- Editorial Board Cardiovascular Engineering and Technology, 2018-present
- Guest editor Special issue Thrombosis and Heamostasis March 2016
- Guest editor Special issue Journal of Biomechanics, 2016
- 2017-2018; Executive Committee, BED ASME
- 2015-present: Member of the Biofluids Committee, BED ASME