Fluorescence-Guided Surgery Group

To focus our activities in this rapidly expanding research field, we have formed the Fluorescence-Guided Surgery Group. The group includes all researchers that are involved in this field, extending over 14 different disciplines. Our vision is that close collaboration will empower us as a group to facilitate more efficient and productive research lines. By forming trans-disciplinary partnerships, we are focusing on new clinical trials, improved coordination of the use of imaging facilities, coordinated and combined efforts for investments in new imaging devices and of research funding, and communication with secondary partners such as the pharmacy, medical ethical committee (METC), and the technology transfer office (TTO). This initiative flourishes through our close partnership with pioneering researchers at the Leiden University Medical Centre.

• Intraoperative tumor-specific fluorescence imaging of oral cancer (“Guided by Light” trial) and laryngeal/hypopharyngeal cancer (“STELLAR” trial)
• Fluorescence imaging of recurrent and locally advanced rectal cancer using SGM-101
• Complementary use of fluorescence-guided surgery and Raman spectroscopy
• Vascular perfusion of anastomosis and reconstructive surgery

2021:  
Real-time fluorescence imaging in intraoperative decision making for cancer surgery
Lorraine J Lauwerends, Pieter B A A van Driel, Robert J Baatenburg de Jong,
José A U Hardillo, Senada Koljenovic, Gerwin Puppels, Laura Mezzanotte,
Clemens W G M Löwik, Eben L Rosenthal, Alexander L Vahrmeijer, Stijn Keereweer.
The Lancet Oncology Published online March 22, 2021 doi.org/10.1016/S1470-2045(20)30600-8.
https://pubmed.ncbi.nlm.nih.gov/33765422/ 

2021:
Fluorescence-guided surgery in colorectal cancer; A review on clinical results and future perspectives.
Galema HA, Meijer RPJ, Lauwerends LJ, Verhoef C, Burggraaf J, Vahrmeijer AL, Hutteman M, Keereweer S & Hilling DE.
Eur J Surg Oncol. 2021 Oct 9:S0748-7983(21)00755-1. doi: 10.1016/j.ejso.2021.10.005.
https://pubmed.ncbi.nlm.nih.gov/34657780/

2021:
Current Intraoperative Imaging Techniques to Improve Surgical Resection of Laryngeal Cancer: A Systematic Review.
Lauwerends LJ, Galema HA, Hardillo JAU, Sewnaik A, Monserez D, van Driel PBAA, Verhoef C,
Baatenburg de Jong RJ, Hilling DE, Keereweer S.
Cancers (Basel). 2021 Apr 15;13(8):1895. doi: 10.3390/cancers13081895.
https://pubmed.ncbi.nlm.nih.gov/33920824/

Department of Otorhinolaryngology Head and Neck Surgery

Department of Surgical Oncology and Gastrointestinal Surgery

Department of Radiology & Nuclear Medicine

Department of Plastic Surgery

Department of Molecular Genetics

Department of Surgical Oncology, Leiden University Medical Center 

2020:      Maurits en Anna de Kock Stichting
PI: Stijn Keereweer, Tessa van Ginhoven
Title: “Improving surgical removal of oral cancer using fluorescence-guided surgery.”
Funding: €40.000,00

2019:      Daniel den Hoed Award / Erasmus MC Fund
PI: Stijn Keereweer (Personal Grant)
Post-doc: Hamed Abbasi
Title: “Improving surgical removal of oral cancer using a unique, innovative combination of fluorescence-guided surgery and Raman spectroscopy”
Funding: €250.000,00

2019:      Young Investigator Grant from the Dutch Cancer Society
PI: Stijn Keereweer (Personal Grant)
PhD student: L. Lauwerends
Title: “Guided by light: Optimizing surgical excision of oral cancer using real-time fluorescence imaging”
Funding: €497.935,00

2019:      Applied Efficiency Grant / Erasmus MC
PI: Dirk Grunhagen, Stijn Keereweer
PhD Student: E. Mulder
Title: “MOTOR pilot study - Ex Vivo Application of Multispectral Optoacoustic Tomography & Reflectance Spectroscopy in Lymph Nodes and Pigmented Tissue”
Funding: €86.108,00

2019:      Maurits en Anna de Kock Stichting
PI: Stijn Keereweer, Elisa Barroso
Title: “Improving surgical removal of oral cancer using an innovative combination of fluorescence-guided surgery and Raman spectroscopy.”
Funding: €36.370,00

2018:      Dutch Cancer Society Consortium Grant
PI: Denise Hilling, Kees Verhoef, Alexander Vahrmeijer (LUMC), Harm Rutten (CZE)
PhD student: Job van Kooten, Hidde Galema, Jan van Rees
Title: Tumour-specific near-infrared fluorescence imaging in locally advanced and recurrent rectal cancer
Funding: €1.071.553,00

  Department of Otorhinolaryngology:

• Stijn Keereweer (principal investigator)
• Prof. Robert Jan Baatenburg de Jong
• Dominic Robinson
• Hamed Abbasi
• Lorraine Lauwerends (PhD candidate)
• Hidde Galema (PhD candidate)

   

  Department of Surgical Oncology:

• Denise Hilling (principal investigator)
• Prof. Kees Verhoef
• Tessa van Ginhoven
• Dirk Grunhagen
• Hidde Galema (PhD candidate)
• Job van Kooten (PhD candidate)
• Evalyn Mulder (PhD candidate)
• Pierre Ambrosini (PhD candidate)
• J.M. van Rees (PhD candidate)

   

  Department of Radiology & Nuclear Medicine:

• Prof. Clemens Lowik
• Laura Mezzanotte
• Prof. F.A. Verburg

   

  Department of Plastic Surgery:

• Dalibor Vasilic
• Prof. Marc Mureau
• Eveline Corten

   

  Department of Cardiothoracic Surgery:

• Lex Maat
• Edris Mahtab

   

  Department of Gynaecological Oncology:

• Lena van Doorn
• Heleen van Beekhuizen
• Gatske Nieuwenhuyzen-De Boer
• Nick van de Berg

   

  Department of Neurosurgery:

• Prof. Clemens Dirven
• Arnaut Vincent
• Rutger Balvers

   

  Department of Gasteroenterology and Hepatology:

• Wilmar de Graaf

   

  Departement of Cardiology:

• Prof. Gijs van Soest

   

  Department of Molecular Genetics and Radiation Oncology:

• Jeroen Essers
• Kranthi Panth
• Sharline Perez (PhD candidate)

   

  Department of Urology:

• Prof. Joost Boormans
• Sytse van Beek

   

  Department of Vascular Surgery:

• Jorg de Bruin

   

  Department of Viroscience:

• Rik de Swart
• Rory de Vries

   

  Department of Pathology:

• Sjors Koppes

   

  Department of Surgical Oncology, Leiden University Medical Center 
  Alexander Vahrmeijer, Dept. of Surgical Oncology
  
  
  Isala Hospital, Zwolle:
  Pieter van Driel, Dept. of Orthopedic Surgery

Any questions or comments?

Please contact our office.