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Research project  |  Physiotherapeutic Treat-to-target Intervention after Orthopaedic surgery; a cost-effectiveness study (PaTIO trail)


To evaluate the cost-effectiveness of the optimized, treat-to-target PPT strategy in TKA and THA patients compared to usual PPT. The hypothesis is that with the optimized strategy superior functional outcome can be achieved to usual care, with lower costs (superiority study).

What we do

About our project

Research question
Provides the “treat-to-target” postoperative physical therapy after THP and TKP better functional outcomes at lower costs compared to the usual PPT after THP and TKP?

Study population
Patients with clinical and radiological knee or hip osteoarthritis (OA) who are scheduled for a primary TKA or THA.


LUMC Leiden 

Alrijne Leiderdorp
Bergman Clinics Rijswijk 
CWZ Nijmegen
Diakonessenhuis Utrecht
ETZ Tilburg
HAGA den Haag
MMC Eindhoven
MC Leeuwarden
UMC+ Maastricht
NWZ Alkmaar
OLVG Amsterdam
Spaarne Gasthuis Hoofddorp
Tergooi ziekenhuis Hilversum
UMC Groningen
Ziekenhuis Gelderse vallei
Zuyderland Sittard-Geleen


Groot L, Gademan MGJ, Peter WF, van den Hout WB, Verburg H, Vliet Vlieland TPM, Reijman M; PaTIO study group. Rationale and design of the PaTIO study: PhysiotherApeutic Treat-to-target Intervention after Orthopaedic surgery. BMC Musculoskelet Disord. 2020 Aug 14;21(1):544. doi: 10.1186/s12891-020-03511-y. PMID: 32795283; PMCID: PMC7427768.

Our team

dr. Mw. M. Gademan

prof. dr. Mw. T. Vliet Vlieland

dr. Dhr. W. Peters